Abstract

To admix and characterize novel pyrimidine derivatives and screening them for anti-anxiety activity. A series of four 6, 7-dihydro-3-aceto substituted pentaleno [2, 1-d] pyrimidin-4-one derivatives (PM1-PM4) were synthesized from 2-amino-3, 4, 5, 6-tetra hydro pentalene-1-carboxamide. The obtained compounds were characterized on the basis of satisfactory analytic and spectral (H1NMR, C13NMR, Mass and Elemental) data. Studies were agitated out for the novel compounds which were evaluated for anti-anxiety action by Forced Swimming Test (FST) model and Avoidance Exploratory Behaviour Test (AEBT). Diazepam is used as standard anti-anxiety agent. The synthesised compounds showed adequate anti-anxiety activity, compared to accustomed drugs. Two of the compounds PM1 and PM3 credible cogent anti-anxiety activity, as compared to accustomed biologic Diazepam. Hence, the synthesized novel pyrimidine derivative may be considered as potent anti-anxiety agents.