Abstract
The present investigation is concerned with development and evaluation of floating tablets containing Norfloxacin. Usingthe hydrophilic polymer hydroxy propyl methyl cellulose (HPMCK100M), gas generating agent sodium bicarbonate and citric acid. A 32 factorial design was applied systematically; the amount ofcitric acid (X1) and amount of HPMCK100M (X2) were selected as independent variables. The dependent variables chosen werepercentage drug release at 8hrs. (Q8), percentage drug release at 12 hours (Q12) and floating lag time that high level of HPMC K100M and citric acid favours preparation of floating sustained release tablet of norfloxacin. The granules were prepared by wet granulation method and evaluated for their granules properties. Tablets were compressedby KarnavatiRimek Mini press1 and evaluated with different parameters like diameter, thickness, average weight, hardness, friability, drug content, in vitro buoyancy study, swelling characteristics, and kinetic release data. The in-vitro release studies indicated that the floating dosage forms containing higher concentration of HPMC K100M showed slower release. The in-vitro release data was treated with mathematical equations, and it was concluded that norfloxacin released from the tablet followed Peppas model with Non-Fickian diffusion. Hence floating drug delivery system of norfloxacin is a promising approach as it can lead to decrease in the frequency of administration and ultimately lead to better patient compliance.
