Abstract
In the present investigation, a series of novel 3-(4-substituted-phenyl)-9-methyl-thieno[3,2-e] [1,2,4]triazolo[4,3-c]pyrimidine-8-carboxylic acid (4-substituted-benzylidene)-hydrazide (5a-o) were synthesized and developed as better antimicrobial agents. The chemical structure of the newly synthesized compounds were characterized by spectral (IR, 1H NMR, 13C NMR, LC-MS and CHN analysis) methods. It was observed that the compounds with chloro substituted thieno[1,2,4]triazolopyrimidine showed better antimicrobial activity. The compound (5a) showed significant antibacterial activity against B. subtilis with MIC 1.56 μg/mL and antifungal activity against A. niger with MIC 1.56 μg/mL as compared to the standard drugs. Herein we wish to report the synthesis and antibacterial efficacy of a new series of 1,2,4-triazole and Schiff’s bases bearing thienopyrimidine moiety (5a-o).
