Abstract
The aim was to develop the medicated lipstick using natural ingredients. The drug used in the formulation is Terbinafine hydrochloride which is used for anti-fungal therapy. Preformulation studies revealed that API and excipients were found to be compatible. For the formulation of lipstick Box-Behnken design was used. Three factors three level design selected on the basis of preliminary trials. Three independent factors like concentration of bees wax, concentration of carnuba wax and Concentration of Isopropyl myristate were selected. Quadratic model was selected for the prediction of the responses of dependent variables such as hardness (R1) and drug release (R2). Response surface plots were drawn to find out the optimized formulation. Evaluation test like breaking load test, softening point, permiability, melting point and antifungal activity was performed on the finalized formulation.
