Abstract
Some novel 4-(2-amino-3-cyano-4-(substituted-aryl)-5- oxo-5,6,7,8-tetrahydroquinolin-1(4H)-yl)benzene sulfonamide (1a–1u) were were synthesized starting with 4-(3-oxo-cyclohex- 1-enylamino)benzene sulfonamide and 4-(cyclohexenylamino) benzene sulfonamide in the synthesis of some novel 4-(quinolin-1-yl) benzene sulfonamide derivatives. The structures of the synthesized compounds have been elucidated by IR, 1H NMR and elemental analysis. Synthesized compounds were screened for their antimicrobial screened against the E.coli and staphylococcus aureus, Salmonella typhi, Bacillus subtilis, Escherichia coli and antifungal activity against Aspergillus niger, Penecillium crysogenum, Aspergillus flavus, and Candida albicans.
