Abstract
Gastroretentive dosage forms have potential use as controlled-release drug delivery systems. A controlled release system which is designed to increase its residence time in the stomach without contact with the mucosa was achieved through the development of Microballoon drug delivery system using emulsion solvent diffusion method. The effect of various formulation and process variables on the internal and external morphology, micromeritic properties, in vitro buoyancy, physical state of the incorporated drug, drug loading and in vitro drug release was studied. Formulation (BT3) demonstrated favourable buoyancy,drug loading,drug release characteristics and encapsulation efficiency. The designed system, which has excellent buoyant ability and suitable drug release pattern, will possibly be useful in terms of increased solubility and bioavailability of Valsartan. The prepared Valsartan loaded Microballoon were found to be stable at various conditions.
