Abstract

Taste is an important factor in the development of dosage form. Certain drugs that have very bitter taste can be made relatively tasteless by adsorbing the drug on ion exchange resin although all the ion exchange resins can be useful for this purpose, the proper selection on ionic character of drug and release characteristics. The main objective of the present invention is to provide an oral composition which can deliver a pharmacokinetically acceptable dosage of a beneficial agent, or to at least provide the patient with a useful choice and to provide a taste masked composition. Levofloxacin hemihydrate is very bitter in taste and mostly used for pediatric suspensions to treat the infections.Tulsion-335, ion exchange resin, was used to mask the bitter taste of drug. In this research work firstly prepare the drug resin complexes in different ratios by batch method and evaluated for various parameters including tastemasking. After successful preparation of DRC, the complexes were used to formulate taste masked suspension. Taste masked suspension was also evaluated for taste masking and in-vitro release study. Formulated suspension was compared with marketed levofloxacin syrup and calculated the similiarity factor. Accerlated stability study was also performed for one month. Based on the evaluation data obtained after one month stability study, it was concluded that the formulated suspension with SDRC was successfully taste masked, stable and reproducible in nature.