Abstract
The aim of the study is to prepare anti-reflux formulation of potential proton pump inhibitor (PPI) such as Rabeprazole sodium (RPS). RPS is a potential PPI, only 20 mg once in day is sufficient and also has some anti-microbial activity against H. Pylori. The anti-reflux formulations are type of GRDDS which used to prevent Gastro Esophageal Reflux Disorder (GERD) known as Esophagitis. The esophagitis occurs due to the over exposure of refluxate of the stomach. Thus anti-reflux formulations are used to which inside the stomach forms the mechanical barrier above the chymes and below the lower esophageal sphincture. Thus for effective raft formation various raft forming agents are used; out of which two are selected and studied for anti-reflux formulation. The formulation was evaluated for the suspension as well as raft formed by the suspension in vivo. Raft forming used was Sodium alginate and Guar gum, both are from natural origin and have marked advantage as compared to other raft forming agents. Along with raft-forming agent other excipients such as gas generating agents, divalent cation generator and preservatives were used. The pH of the suspension was made at neutral pH as RPS is unstable in lower pH.
