Abstract
The aim of this study was to prepare and characterize Zaltoprofen nanosuspensions to enhance dissolution rate and oral bioavailability of this drug. Nanosuspensions were prepared by the Quassi emulsification solvent diffusion method. The effect of process parameters like stirring speed, Stirring time along with concentration of polymers on particle size were studied systematically. The particle size of the formulation was determined by scanning electron microscopy (SEM) observation. The formulations were analyzed for particle size using SEM, Zeta potential determination IR& DSC Studies, in vitro drug release studies. The particle size of the formulated nanosuspensions were found in the range of 92-200nm. Quassi emulsification solvent diffusion method can be used for preparation of nanosuspension.
