Abstract

The objective of this study was to develop mucoadhesive buccal tablets of Losartan Potassium using both Synthetic and Natural mucoadhesive polymers and evaluate results of both polymers. Losartan Potassium is Angiotensin receptor blocker having short biological half-life (2hr), high first-pass metabolism and poor oral bioavailability (33%), hence an ideal candidate for buccal delivery system. The buccal tablets of 150 mg were prepared by using synthetic (Carbopol 934p as primary and HPMC K15M and SCMC as secondary polymer) and natural polymers (Sodium Alginate as primary and Guar Gum and Xanthan Gum as secondary polymers) separately in various concentrations by direct compression method, twelve batches were formulated. Estimation ofLosartan potassium was carried out spectrophotometrically at 250 nm. FTIR spectroscopy method revealed that there was no interaction between Losartan potassium and polymers. The tablets were evaluated for hardness, thickness, weight variation, drug content, and surface pH, swelling index, In-vitro drug release, mucoadhesive strength and In-vitro residence time. Among synthetic polymers FB3 and FB6 batches showed better results and from natural polymers batches FB9 and FB12 showed better results. The Ex-Vivo diffusion study of best release batches FB3, FB6, FB9 and FB12 were performed by using Goat buccal membrane on Franz diffusion Cell Apparatus. Data of In-vitro release from tablets were fed into kinetic models (Zero order, first order, Higuchi and Korsmeyer-Peppas models) to explain release profiles. The best formulations batch FB3 showed Korsmeryer-Peppas order release.