Abstract
Diabetes mellitus is a group of metabolic disorder characterised by hyperglycemia and glycosuria with disturbance in carbohydrate, lipid and protein metabolism resulting from relative deficiency of insulin secretion or action. Reactive oxygen species are common by product of many oxidative biochemicals and physiological processes. Antioxidant enzymes such as SOD, catalase, GPx and GR are the first line of defence against oxidative stress. Decrease the activities of these enzymes change redox status of the cell. Present studies clearly showed a dose and exposure frequency dependent decrease in the activities of SOD, CAT, GPx and GR in brain and liver of diabetic rat tissues. Diabetic rats were treated with oral administration of Aegle marmelos and Azadirachta Indica plant extracts increase the activity of antioxidant enzymes and decrease of blood glucose levels as compared to normal control rats. These herbal plant extracts showed hypoglycemic and hypolipidimic effect on diabetic rats.
