Abstract

Oral controlled release drug delivery have recently been of increasing interest in pharmaceutical field to achieve improved therapeutic advantages, such as ease of dosing administration, patient compliance and flexibility in formulation. Drugs that are easily absorbed from gastrointestinal tract (GIT) and have short half-lives are eliminated quickly from the systemic circulation. To avoid this limitation, the development of oral sustained-controlled release formulations is an attempt to release the drug slowly into the gastrointestinal tract (GIT) and maintain an effective drug concentration in the systemic circulation for a long time. The present study involves preparation of floating tablet of Guaifenesin with HPMC K100 M and HPMC K15M floating tablet were designed to achieve the extended release or retentions in GIT which may result enhance in absorption n leads to increment in bioavaiblity. Enhanced floatability of tablet and its retentions period in GIT directly enhanced bioavaiblity of drug and decreases the frequency of administration of drug. Comparing the HPMC polymer grades K100 and K15 it concludes that the K100M shows good result in a F4 batch.