ABSTRACT: 

Amitriptyline was the first tricyclic used to treat neuropathy and it is still widely prescribed. It is a balanced serotonin and nor adrenaline reuptake inhibitor; Bupropion is an atypical antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor  and Venlafaxine, a chemically novel antidepressant, has demonstrated effectiveness in the treatment of pain associated with diabetic peripheral neuropathy in several case reports. Present study was undertaken to compare the effectiveness of venlafaxine, bupropion with amitriptyline in diabetic neuropathic pain.  It was an open, parallel, prospective and randomized type study conducted at the outpatient departments of medicine and neurology of Era’s Lucknow Medical College & Hospital, Lucknow and Chhatrapati Shahuji Maharaj Medical University, Lucknow, respectively, to compare the effects of venlafaxine, bupropion and amitriptyline in patients suffering from diabetic neuropathic pain. The present study aimed at evaluating better treatment with efficacy, better safety profile and positive impact in quality of life in patients of diabetic neuropathic pain. The objective of this study was to assess and compare the effects of venlafaxine, bupropion and amitriptyline in patients suffering from diabetic neuropathic pain.