Abstract
A series of ten new tri-arm star shaped chalcones were synthesized using 2,4,6-tris(4-acetylphenoxy)-1,3,5-triazine as a template. The intermediate 2,4,6-tris(4-acetylphenoxy)-1,3,5-triazine was synthesized by the reaction of cyanuric chloride with sodium salt of 4-hydroxy acetophenone using phase-transfer catalyst. Thus, the prepared 2,4,6-tris(4-acetylphenoxy)-1,3,5-triazine has been subsequently treated with various aldehydes to afford title compound in excellent yields. The structures of intermediate and newly synthesized tri-arm star shaped chalcones were confirmed by physical and spectral analysis. All the tri-arm star shaped chalcones were evaluated for antibacterial and antifungal activities. Selected tri-arm star shaped chalcones showed good to excellent antibacterial and antifungal activities with reference to the well-established standards.
