Abstract

This study emanates from the current industrial requirements keeping in view of the advancements in tablet manufacturing and was aimed towards the development of novel co-processed excipient comprising of corn starch and sodium lauryl sulphate for use in direct compression technique of tableting which we were able to do successfully. The co-processed excipient to be prepared could be able to overcome the flowability drawbacks of individual excipients and also could improve their characteristic properties. Corn starch and Sodium lauryl sulphate were selected for co-processing. The co-processed excipients were prepared by two methods; solvent evaporation method and co-grinding method. Initially, the co-processed excipients were prepared by solvent evaporation method using three solvents out of which water was selected as best solvent based on the flow properties. Large scale preparation of the co-processed excipient was carried out with water as solvent and by solvent evaporation method. Three best ratios were screened out (3:7, 4:6, 5:5 of Corn starch: SLS) based on their performance in flow properties and were chosen for further studies. However, co-processed excipients prepared by co-grinding method are ignored since they have shown poor performance in flow properties. The flowability of the prepared co-processed excipient (CoP CS-SLS) is compared with that of the individual excipients. The comparative study exhibited improvement in flowability. The FTIR study was carried out to check the compatibility between the excipients and it was proved that there are no unwanted interactions and thus proven the co-processing is a novel approach. It can be concluded that the CoP CS-SLS was successfully blended with proven improved flowability and good compatibility.