ABSTRACT:
Study was undertaken to investigate the Impact of social isolation on various oxidative stress markers and transaminase level in rats. Rats were subjected for short (21 days) and long term (up to 84 days) social isolation; the rats displayed an increase in anxiety on elevated plus maze and open field test relative to control. Various markers of oxidative stress like lipid peroxidation (LPO), reduced glutathione (GSH), Supers oxide dismutase (SOD), catalase (CAT) and biochemical parameters like SGOT and SGPT were determined. There was significant increase in the level of LPO and decrease in the levels of GSH, SOD and CAT after long term isolation in plasma and liver. Biochemical parameters were significantly altered after long term isolation. Results indicate that increase in oxidative stress in anxiety which may leads to alteration of biochemical parameters.
