Abstract
The present research has systematic approach to synthesized a series of benzothiazolyl and benzimidazolyl substituted derivatives and to study their antimicrobial activity. The compounds were synthesized by green chemistry technique. i.e. (1-Benzothiazol-2-yl-[1,2]diazetidin-3-ylidene)-(4-phenyl-thiazol-2-yl)-amine, (1-Benzothiazol-2-yl-[1,2]diazetidin-3-ylidene)-substituted phenyl-amine (1c-1i) were prepared from 1-Benzothiazol-2-yl-[1,2]diazetidin-3-one and (1,2-Dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-3-ylidene)-(4-phenyl-thiazole-2-yl)-amine from 1,2-Dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-3-one. Antimicrobial study of these series of compounds was implemented with respect to Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus. Structures of all the newly synthesized compounds were confirmed by their IR, 1H-NMR and CHN analysis. The selected compounds may be used to design more potent biologically active compounds.
