Abstract
The present study investigate the Antidepressant activityof poly herbal methanolic extraction (Rhodiola Rodantha Rhizomes, Blepharis Maderaspatensis seed, Celastrus Paniculatus whole Plant , Brassica Caulorapa Bud) by using Forced swim test and tail suspension test. Many of its individual constituents have been used for central nervous system (CNS) activities but no systematic work was carried on this combination. In this study its effect on depression was explored in rats. Acute and Subacute toxicity study revealed the dose upto 2000mg/kg the extract had not toxic symptoms and no mortality. The therapeutic dose was found to be 200mg/kg, 300mg/kg and there was no toxic damage to liver and kidney observed in subacute toxicity study. The methanolic extract of the polyherbal combination exhibited significant (P<0.001) antidepressant activity as indicated by its ability to decrease swim stress and tail suspension induced immobility time in rats as compared with that standard Fluoxetine. The result indicates this polyherbal combination can be a potential candidate for .managing depression. However further studies are required to confirm the exact therapeutic efficacy.
