Abstract

Objective: To evaluate the antidiabetic potential of ethanolic extract of Hugonia mystax leaves in Streptozotocin-nicotinamide induced diabetic rats. Methods: Group I = Control (Animal received Normal saline- 1ml/kg), Group II = Diabetic Control (Animal received Streptozotocin-nicotinamide 150mg/kg), Group III = Animal received ethanolic extract of Hugonia mystax leaves (200mg/kg), Group IV =Animal received ethanolic extract of Hugonia mystax leaves (400mg/kg) and Group V=Animal received Glibenclamide (5mg/kg) respectively. Results: The results of the study indicates that Hugonia mystax leaves extract significantly (P<0.01) reduced the blood sugar level. The leaf extract also significantly reduced the levels of serum cholesterol, triglycerides, and low density lipoprotein and increase HDL levels in diabetic rats. The leaf extract significantly (P<0.01) decrease in the elevated alkaline phospatase, SGOT and SGPT in Streptozotocin-nicotinamide treated rats and the level significantly (P<0.01) restored to normal level after treatment. Conclusions: Ethanolic extract of Hugonia mystax leaves has protective effects on the protection of vital tissues (pancreas, kidney, liver, heart and spleen), thereby reducing the causation of diabetes in experimental animals.