Abstract
Fast disintegrating tablets are the solid dosage forms consist of drugs that disintegrate in the oral cavity within less than one minute leaving an easy to swallow residue. The demand for FDT’s has been growing during the last decade especially for elderly &children who have swallowing difficulties. In this research work we have developed Loratidine fast dissolving tablet using natural superdisintegrants. Loratidine is usually used alone or in combination with pseudoephedrine sulphate for the symptomatic relief of seasonal allergic rhinitis, pruritis, erythemia & urticaria associated with chronic idiopathic urticaria. The oral bioavailability of Loratidine is around 40% with biological half life of 8.4 hrs. In the present work FDT of Loratidine were prepared primarily using solid dispersion to enhance solubility & then FDT’s were prepared using natural superdisintegrants viz Isapgol & Fenugreek. The prepared tablets were evaluated for Pre & post compressional parameter. The FDT’s using solid dispersion & natural superdisintegrants passes weight variation in the range of 100 ± 0.65 SD to 106 ± 0.86 SD & hardness was 2.1 to 2.6. % Friability 0.819 to 0.983 disintegration times was 40-58 seconds & in-vitro drug release 71.24 to 86.00% at the end of 30mins from F1 to F4 & which was fitted to pharmacokinetic model & it shows zero order drug release. From FTIR study reveals that there is no interaction between drug & the excipients used for FDT. The results concluded that FDT of Loratidine showing increased dissolution rate may lead to increased bioavailability by using solid dispersion.
