Abstract
The Present investigation an attempt has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance, by developing SR Matrix tablets of Bosentan is an Endothelin Receptor Antagonist (ERA) indicated for the treatment of Pulmonary Arterial Hypertension (PAH). Bosentan Sustained Release Matrix Tablets were prepared by using different natural polymers like Xanthan gum, Guar gum, Pectin at different ratios of Drug: Polymer. The Matrix tablets were prepared by Wet granulation method. The prepared tablets were selected for DSC and FTIR studies. The tablets were selected for DSC and FTIR studies did not show any chemical interaction between drug and polymer. The prepared tablets were evaluated for various Physico chemical parameters. Invitro drug release study was carried out in simulated gastric fluid (0.1N Hcl) for the first 2 hours and in Phosphate buffer (PH 6.8) for the next 10 hours following USP Paddle method. The release kinetics was analyzed using the Zero-order, first order model equation, Higuchi’s- square root equation, and Korsmeyer-Peppas model. Among the all formulations, F7 formulation containing Drug to Pectin in ratio 1:0.5 is optimized based on its ability to sustain drug release till 12 hrs of dissolution study. The Optimized formulation F7 showed zero order release with fairly linear as indicated by their high regression values (R2 = 0.9928). Results revealed that F7 formulation follows the zero order transport mechanism.
