Abstract
Microspheres can be tailored to provide targeted and/or sustained release in different parts of the body, including those of eye, nasal cavity, urinary, colon and gastrointestinal tract, thus offering the possibilities of localized as well as systemic controlled release of drugs. Prolonged release of drugs and a reduction in frequency of drug administration can highly improve the patient compliance. Recent advances in targeted drug delivery and sustained release of drug uses this mechanism even for the delivery of protein and peptide drugs, antigens for vaccination and plasmid DNA for gene therapy. In the present work we have developed the formulation of microspheres for an antiretroviral drugs combination of Lamivudine and Stavudine which has less plasma half life hence it is necessary to develop the formulation which will provide the sustained release of the drug thereby reducing the dose of the drug. We developed and characterized the microsphere formulation which improved the efficacy of the drug and hence reduce the side effects. Characterization also showed that there is no drug excipient interaction. The Physical characteristics like Particles size, Drug entrapment, FTIR, SEM, XRD,DSC and In-vitro drug release profiles will be studied.
