Abstract
Through medication increasing number of novel drug delivery systems are being employed to manage illness and are offered for therapeutic use. Gastro retentive drug delivery systems have potential to permit improved penetration of the mucus layer and as a result better concentration of drug at the specific site ,ensure optimal bioavailability to poorly absorbed drugs and a desired release profile. This drug delivery system potentially overcomes a drawback of non-site specificity and short gastric resident time that are associated with oral route of administration. At present numerous approaches are utilized to prolong the gastric residence time, Including floating systems, Magnetic system swellable/expanding systems, gastric mucohedhesive systems, sedimentation /high density system by incorporating suitable polymers in dosage form. This study describes the different structural components like polymers and other excipients (formulation variables) that can be utilized to formulate the suitable and effective gastro-retentive drug delivery system. In the aspect of recent development, different formulation variables that have direct effect on gastric residence time, floating, high density, bioadhesion, expending and magnetic properties of GRDDS are covered in detail in this review.
