Abstract

Cyperus rotundus is a traditional herbal medicine used as analgesic, sedative antispasmodic, antimalarial, stomach disorders and to relieve diarrhea. Diabetes is a group of metabolic disorder of carbohydrate, fat, and protein metabolism resulted from destruction of insulin secreting pancreatic beta-cells, defects in insulin production, insulin action, or both, characterized by hyperglycemia. In the present investigation the ethanolic extracts of Cyperus rotundus has been screened for the presence of phytoconstituents, acute toxicity, hypoglycemic, antidiabetic activity and wound healing activities.The plant extract is obtained by using soxhlet apparatus extraction procedure and phytochemical studies of ethanolic extract showed the presence of alkaloids, steroids, tannins, phytosterols and flavonoids.Acute toxicity studies have revealed that the ethanolic extract of Cyperus rotundus were safe upto 2000 mg/kg..The ethanolic extract of Cyperus rotundus showed the significant decrease in serum glucose level (p< 0.001) in both oral glucose tolerance test and alloxan induced diabetic rats. There is also a significant reduction in serum triglycerides, total cholesterol, LDL, and liver enzymes. The reduction in wound contraction was statistically significant as compared control group. So we can conclude that ethanolic extract of Cyperus rotundus has shown significant antidiabetic, antihyperlipidimic and wound healing activity in alloxan induced diabetic rats.