A simple and sensitive kinetic spectrophotometric method has been successfully developed for the determination of Eperisone hydrochloride based on its oxidation using potassium permanganate in alkaline medium. The rate of change of reaction was recorded at 603.5 nm. The different experimental parameters were studied and optimized. 5 minutes and 3 minutes were chosen for the development of initial rate and fixed time method respectively. Calibration curve was found to be linear over the concentration range of 15-35 µg/ml for initial rate method and 15-30 µg/ml for fixed time method. The method was applied for estimation of eperisone hydrochloride in RAPISONE (marketed by Abbott, Maharashtra). The assay results were found to be 99.93% ± 0.05 and 99.42% ± 0.05 by initial rate and fixed time method. RSD values were found to be ≤2%. The results were validated as per the ICH guidelines.