Abstract
The present Study is to evaluate the Antioxidant and Hepatoprotective Activity of Extracts of Flowers of Tridax Procumbens Linn, against Dgalectosamine induced Hepatotoxicity in Male Wister Albino Rats.The flowers of Tridex procumben Linn. Was extracted out by petroleum ether, methanol and chloroform water. The phytochemical investigation and its Phenolic content were determined. The antioxidant activity was evaluated by two methods reducing power ability method and lipid peroxidation method. The dose of the extract was fixed by acute oral toxicity as Per OECD guideline 423. Then it was subjected for Hepatoprotective activity on rats by Dgalectosamine induced model and Histopathological changes were also observed. The yield of the drug was 2.22% and 2.5% in Methanolic and Aqueous extract. The extracts contain Alkaloids, Flavanoids, Carbohydrates, and Tannins etc. The total Phenolic content found to be 59.87 and 53.12 μg/ml as compared to the gallic acid. In the Hepatoprotective Activity the extracts shows significant effect. But as compared to aqueous extract, the Methanolic Extract shows potent effect.
