Abstract
Appreciable number of five membered and six membered heterocyclic containing nitrogen, oxygen and sulphur atoms has turned out to be potential chemotherapeutic and pharmacotherapeutic agents. Various useful synthetic analogues with improved therapeutic properties can be obtained from pyrimidine derivatives. Many classes of chemotherapeutic agents containing pyrimidine derivatives are in clinical use such as antimicrobials, antitumour, antitubercular, antihistamines and antioxidants. Pyrimidine forms a large group of among the pharmacologically active moieties. Several heterocyclic substituted pyrimidines have also been reported to possess a wide spectrum of biological activities. In the present work, based on the prominent biological activities of pyrimidine derivatives, it was decided to synthesis some novel Schiff base fused pyrimidine derivatives and screen them for their antimicrobial activity.
