Gastro retentive drug delivery is a new approach for prolonged gastric residence time, for targeting the specific site in the gastro intestinal tract (GIT). Such a system can retain in stomach for prolonged period of time and hence there by prolonging the duration of action, thereby increasing the gastric retention of the drugs. In-situ gels are capable of producing the sustained and controlled drug delivery, they are having more advantages such as ease of administration and patient compliance. In situ floating gels were prepared by using guar gum(F1- F4) and gum karaya (F5 – F8), the % drug release for the formulations F1-F4 were found between 73.14% - 70.81% and for F5 to F8 the % drug release were found between 55.16% - 78.15%. Release kinetics showed that pure drug, F1, F3, F4, F5, F8 followed Higuchi release model, F2 and F7 followed Krosmeyer release model and F6 followed Zero order release model.
