In the present study, methanolic extract of aerial roots of Ficus bengalensis was screened for hypoglycemic and antihyperglycemic activity with in-vivo models in normal, glucose loaded and streptozotocin induced diabetic rats(at doses of 100, 200 and 300 mg/kg b.w.) The methanolic extract of Ficus bengalensis showed significant hypoglycemic activity with normoglycemic rats (p<0.01), oral glucose tolerance test (p>0.05) and antihyperglycemic activity (p>0.05) when results were compared to the standard drug, Glibenclamide (0.25 mg/kg b. w.). Besides total phenolic and flavonoid content were also evaluated, results showed the significant amount of phenolic and flavonoid content. The results showed that methanolic extract of aerial roots of Ficus bengalensis possesses hypoglycemic and antihyperglycemic activity. Aerial roots of Ficus bengalensis can be used in the treatment of Diabetes Mellitus.
