The three component synthesis of 2-(Substituted phenyl)-4, 5-bis-(4-methoxyphenyl)-1H-imidazoles a typical catalyzed reaction could be conducted successfully with good to excellent yields. A series of imidazoles derivatives was synthesized by the condensation between 4, 4’-dimethoxybenzil, Substituted benzaldehyde and ammonium acetate in glacial acetic acid solvent .The synthesized derivatives were evaluated for their antimicrobial activities using Gram positive bacteria (Staphylococcus aureus ,and Bacillus substalis ) and Gram negative bacteria (Escherichia Coli and Pseudomonas aeruginosa ) among the tested compounds were found to be more potent antimicrobial drugs. All synthesized compounds were characterized by melting point, IR, 1HNMR spectral analysis and elemental analysis.
