In recent times, controlled and sustained drug delivery has become the standard in modern Pharmaceutical design and an intensive research have been stimulate by the advantages shown by in situ forming polymeric delivery systems such as ease of administration and reduced frequency of administration, improved patient compliance and comfort. In situ gelling systems (type of mucoadhesive drug delivery system) are liquid at room temperature but undergo gelation when in contact with body fluids or change in pH. Sustained and prolonged release of the drug, good stability and biocompatibility characteristics make the in situ gel dosage forms very reliable. Advances in in-situ gel technologies have encourage development in many medical and biomedical applications including controlled drug delivery. Many novel in situ gel-based delivery matrices have been designed and fabricated to fulfill the ever-increasing needs of the pharmaceutical and medical fields. The formulations are designed with an objective to retain in stomach for an extended time period to obtain better bioavailability. In-situ forming polymeric formulations drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation in-situ to form a gel. Many natural, biodegradable, biocompatible and synthetic polymers are used in the preparation of in situ gelling system. Mainly in situ gels are administered by oral, ocular, rectal, vaginal, injectable and intraperitoneal routes. In situ gels were evaluated for their visual appearance, clarity, pH, viscosity, gelling strength, drug content analysis, in-vitro gelation, rheological studies, sterility testing, texture analysis and in-vitro drug release studies.
