Abstract

The marketed α- glucosidase inhibitor like Acarbose, Miglitol and Voglibose are wide used for treatment of DM, apart from these drugs Salacia Oblonga and Salacia Reticulata are plants native to India and Sri Lanka these are widely used for thousands of years in Ayurvedic medicine for the oral treatment of diabetes a chronic disorder in metabolism of carbohydrates, proteins and fat due to absolute or relative deficiency of insulin secretion with/without varying degree of insulin resistance. Attenuation of postprandial glycemia is hypothesized to reduce the risk of progression from impaired glucose tolerance to diabetes. It is also thought to reduce the number of complications associated with diabetes. A clinical trial conducted to assess the comparison of outcome of marketed drugs and its combination with Salacia species, found significant effect on weight and HbA1C value of patients of Type II DM