The aim of current study was to extract the gum from Watermelon (Citrullus lanatus) seeds and to investigate the compressional behavior of gum in tablet formulation in comparison with standard binders such as starch using Heckel and kawakita plot. Using paracetamol as model drug granules were prepared with different concentration (1%, 1.5, 2%, 2.5, and 5%) of the gum and binder by wet granulation method. The granules and tablets were evaluated for their flow properties, hardness, weight variation, thickness etc., and found to have hardness and disintegration time slightly more compared to starch as binder and hence satisfactory for preparing compressed tablets. The study revealed that the Citrullus lanatus seed gum compared favourably with the standard starch as a binder but plasticity of starch is more than Citrullus lanatus seed gum as binder. The Citrullus lanatus seed gum has a potential for formulating sustained release formulations due to prolong drug release.
