Abstract
Along with the globalization and improper nutrition supply many new diseases are emerging in the world. Oxidative decomposition of cellular components leads to some diseases, which are life threatening one. As anti-oxidants are developing as drug candidates for treating these diseases by preventing the oxidative decomposition of cellular components, there is a need for developing some potent anti-oxidant agents. In this research we have synthesized some novel series of thiadiazolidinone and imidazo(2,1-b)-1,3,4-thiadiazole derivatives. The title compounds, thiadiazolidinone 5(a-b) and imidazo(2,1-b)-1,3,4-thiadiazoles 6(a-j) were synthesized by the reaction between Schiff bases of 1,3,4-thiadiazoles with thioglycollic acid in the presence of ethanol and 2-amino-5-(substituted phenyl)-1,3,4-thiadiazoles with different substituted aryl/heteroaryl a-bromoketones in dry ethanol respectively. Structure of the synthesized compounds was confirmed on the bases of spectral data (IR, 1H NMR and Mass). These compounds were screened for anti-oxidant activity using Nitric oxide scavenging and DPPH method. Ascorbic acid was used as standard drug. The results showed that compounds 6c, 6d, 6g, 6f, 6h and 6j exhibited good anti-oxidant activity. The presence of coumarin moiety in the synthesized drugs potentiates the anti-oxidant activity.
