Aim of the present study is to synthesize molecules of chalcone linked arylidene imidazoles as potent bioactive agents. A series of ten novel 4-arylidene-2-phenyl-1-(4-(3-phenylacryloyl)phenyl)-1H-imidazol-5(4H)-ones (9a-j) have been synthesized by the reaction of 1-(4-acetylphenyl)-4-arylidene-2-phenyl-1H-imidazol-5(4H)-ones (7a-f) with different aryl aldehydes in basic media. Intermediates (7a-f) were obtained in good to excellent yields by the condensation of 4-arylidene-2-phenyloxazol-5(4H)-ones (5a-f) with p-aminoacetophenone (6) in the presence of DMF/POCl3 and Zeolite as the catalyst. The structures of the newly synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR and Mass spectral studies. This method can be an efficient method for the synthesis of imidazolones. All the final compounds were screened for their antibacterial, antifungal and antioxidant activities and found to be biologically active. Among all the compounds 9j was found to be potent antimicrobial and antioxidant.
