The current aim of our research work is to explore the potentiality of lip skin as a novelistic platform due to its unique histology and investigate the strip forming property of isolated novel biomaterial by formulating Rosiglitazone loaded bio strip. The strip was formulated using a novel bio material as a film former which was isolated from ripened fruits of Broussonetia papyrifera by simplified economical process and purified by hot dialysis method. The isolated biomaterial (BP) was subjected to various spectral analysis like Fourier Transform-Infra Red, Mass, proton-NMR along with surface electron microscopy (SEM) analysis. Rosiglitazone loaded bio lip strips were formulated by film casting method. The formulated strips were subjected for various evaluation parameters including stability studies, in-vitro and in-vivo drug release. All the formulations exhibited satisfactory characteristics. Release kinetics of bio strips followed Higuchi model and the mechanism of the drug release was diffusion and anomalous type. The release of drug from formulated bio lip strips was found to be extremely significantly (p<0.0001) different. The best formulation was selected on the basis of various evaluated parameters, linearity of drug diffusion rate and used concentration of biomaterial in the formulation. Finally it was concluded that isolated biomaterial could serve as promising excipient for systemic delivery of drugs through labial route and other transdermal route and the drug release data of in-vitro and in-vivo confirmed the delivery of drug through translabial route.
