The Karl Fischer titration is a widely used titrimetric method for water determination in various substances. The determination of water is important to check the product quality and to assure even chemical and physical properties of the product. In the pharmaceutical industry for example stable water content is important for intermediate powders which are formed to tablets. When the powder is too dry, the tablets crumble, when it is too wet, the tablets will stick to the blister foil. The loss-on-drying often used is not suitable for a variety of samples since it determines all volatile material and not only the water content.