A simple, sensitive, accurate and stability-indicating economical densitometric method has been developed and validated for the quantitative determination of Azilsartan medoxomil (AM) in bulk and pharmaceutical dosage forms. Separation of the drug was carried out using ethylacetate - n-hexane 7:3(v/v) as mobile phase on precoated silica gel 60 F254 plates. The retention factor (Rf ) for AM was 0.65 ± 0.05. The detection of band was carried out at 249 nm. The method was validated with respect to linearity, accuracy, precision, robustness and forced degradation studies, which further proves the stability-indicating supremacy of the method. During forced degradation studies, azilsartan medoxomil is observed to be labile to acid, base hydrolysis, oxidative stress and stable in photolytic and thermal stress. The calibration curve was linear in the concentration range 100 to 700 ng per band with correlation coefficient (r2 = 0.999) and is found to be sensitive for azilsartan medoxomil, with a detection limit of 22 ng per band and a quantification limit of 68 ng per band. The recovery study results ranged from 99.26 to 100.65% with RSD values ranging from 0.183 to 2.23%. The assay [%] was 99.786 ± 0.203 in tablet formulation tested. It is proposed for routine analysis of this drug in presence of degradation products in stability study.
