Terbinafine Hydrochloride is novel antifungal drug that is currently approved in many countries for the treatment of fungal infections. It belongs to category of synthetic allylamine antifungal and highly lipophillic in nature and tends to accumulate in skin, nails and fatty tissues. The topical gel of Terbinafine Hydrochloride was prepared by dispersion method to overcome the oral drug delivery system of the drug. Total twenty six formulations of topical gel were prepared using Carbopol 940 and Carbopol 934 polymers and three penetration enhancer propylene glycol, tween 80 and oleic acid were studied to see the permeation enhancement. All formulations were evaluated for pH, drug content, viscosity, spreadability, extrudability and in-vitro permeation study. On the basis of evaluation parameters, it was found that the formulation prepared with Carbopol 934 and penetration enhancer oleic acid 3% showed better permeation as compare to other. The antifungal inhibitory activity of optimized formulation on Candida species was also examined with diffusion method. In-vitro release studies were performed using Keshary-Chien diffusion cell. Release kinetic analyses were done to find the kinetics of drug release.
