The objective of the present work was to prepare and evaluate the dispersible tablets of Amoxicillin Trihydrate, by dry granulation method to enhance patient compliance. Various natural disintegrants used in the study were Ispaghula husk powder, Cassia tora powder, cassia nodosa powder and Gum karaya powder. Total eight batches of tablets were prepared using 5 and 10 % concentration of the different natural disintegrants. The prepared batches of tablets were evaluated for hardness, friability, weight variation, thickness, disintegration time and in-vitro dissolution study. The study reveals that the formulation F2 prepared by dry granulation method exhibits better dissolution, disintegration at low concentration of natural disintegration as compared to the marketed formulation of amoxicillin trihydrate and stability study of best formulation was carried out for a period of 90 days at 40 ± 20C and 75 ± 5% RH. Drug and polymer interaction study done by FTIR and revealed that there is no interaction and concluded that F2 formulation was the best formulation. Tablets containing Ispaghula husk powder showed excellent in-vitro disintegration time and drug release as compared to other formulations. After study of eight formulations F2 showed faster disintegration time and maximum drug release in 40 minutes respectively. Amoxicillin belongs to the category of penicillin antibiotics used in treatments of many types of bacterial infections such as ear infections, bladder infections, pneumonia, gonorrhoea and E.coli or salmonella infections. It was concluded that the dispersible tablets of Amoxicillin trihydrate prepared by dry granulation method using Ispaghula husk powder superdisintegrants for effective therapy.
