Sustained release matrix tablets of Propanolol Hydrochloride using MASRx technology was developed by using different hydrophilic polymers i.e. guar gum, xanthan gum, karaya gum and HPMC K100 in different ratios. Drug polymer interaction was determined by UV spectrophotometer, FTIR and DSC studies. Formulated tablets was prepared by wet granulation method and evaluated for pre-compressional parameters (angle of repose, Hausner’s ratio and Carr’s index) and post compressional parameters i.e. hardness (5.48-5.68 kg/cm2), thickness (3.49-3.58 mm), weight variation (200-202 mg), drug content (96.50-100.12%), disintegration time (5-6 hrs) and in vitro dissolution parameters (F3 shows best release rate i.e. 92.46%). All the parameters showed the result within the standard limits. The results of in vitro drug release showed that as the concentration of gum increases, swelling index also increases proportionately. So, it was concluded that on the basis of dissolution study and kinetic release study of Propanolol Hydrochloride matrix tablets prepared using xanthan gum and HPMC K100 (1:10:10) is the best composition of polymer for achieving sustained release formulation.
