Pulsatile drug delivery systems (PDDS) multiple benefits over conventional dosage forms because of their special features. This system designed according to circardian rhythm of body and drug release rapidly and completely as a pulse after lag time. This system effective for those who can’t administered drug at the time of disease level is intense. PDDS deliver the drug from formulation at the right time, right site of action and in the right amount which provides more benefit than conventional dosages and increased patient compliance.The purpose of writing this review to special focus on the different types, approaches and recent advances involved in the development of the formulation. PDDS are gaining importance in the field of pharmaceutical technology. Diseases like asthma, peptic ulcer, cardiovascular ailments, arthritis and hypercholesterolemia where PDDS are promising. Pulsatile drug delivery system have the potential to bring new development in the therapy of may diseases. Pulsatile drugs deliver the drug while disease condition at peak. At right time and dose as well. These system are useful to several problems encountered during the development of a formulation of pharmaceutical dosage form.
